Ongoing projects in Navarro’s group:
- Design, synthesis, and characterization of coordination compounds as chemotherapeutic agents for the treatment of parasitic diseases and cancer.
- Study of their bioavailability properties include solubility, stability, lipophilicity, etc.
- Understand the role of the main and auxiliary ligands, as well of the transition metal ion contained in the designed metallodrug to reach the target, cross the cell membrane, etc.
- Molecular elucidations of the possible mechanisms of action through identify important biological targets.
- Evaluation of the catalytic activity of selected bioactive coordination compounds.
Recent publications:
1.- Luana Daniel, Arquímedes Karam, Chris Hebert J. Franco, Camila Conde, Adrielle Sacramento de Morais, Joel Mosnier, Isabelle Fonta, Wilmer Villarreal, Bruno Pradines, Diogo Rodrigo M. Moreira, and Maribel Navarro. Inorganic Chemistry. 2024, 63, 17087-17099 (Cover)
2.- José Aleixo de Azevedo-França, Luana Pereira Borba-Santos, Letícia Mota Candal de Matos, Bárbara Verena Dias Galvão, Carlos Fernando Araujo-Lima, Israel Felzenszwal, Wanderley de Souza, Adolfo Horn, Jr., Eduardo S. Neves, Sonia Rozental, Maribel Navarro. Anti-Sporothrix Activity of Novel Copper-Itraconazole Complexes. ChemMedChem 2024, e202400054,1-10. https://doi.org/10.1002/cmdc.202400054.
3.- Giset Y. Sánchez Delgado, Maribel Navarro. An overview of auric compounds as antimalarial agents and their action against essential targets of the parasite. Coordination Chemistry Reviews, v. 503, p. 215633, 2024. https://doi.org/10.1016/j.ccr.2023.215633
4.- José Aleixo de Azevedo-França, Victor Feliciano dos Santos Ramos, Luigi Messori, Fabio Santanni, Lorenzo Sorace, Luana Pereira Borba-Santos, Sonia Rozental, Juliany Cola Fernandes Rodrigues, Maribel Navarro. Synthesis, characterization, and biological evaluation of hybrid copper(II) complexes containing azole drugs and planar ligands against neglected diseases. New Journal of Chemistry, v. 48, p. 2515-2526, 2024.
5.- Legna Colina-Vegas, Mariana da Cruz B. Silva, Caroline de Souza Pereira, Ariane Isis Barros, Joaquim Araújo Nobrega, Maribel Navarro, Matthias Rottmann, Sarah D’Alessandro, Nicoletta Basilico, Alzir Azevedo Batista, Diogo Rodrigo de Magalhaes Moreira. Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle. Chemistry A European Journal. 29, 55, e202301642, 2023. doi: 10.1002/chem.202301642. (Cover).
6.- Camila Aparecida da Silva Dos Reis Condé, Ana Luiza de Andrade Querino, Heveline Silva, Maribel Navarro. Silver(I) complexes containing N-heterocyclic carbene azole drugs: Synthesis, characterization, cytotoxic activity, and their BSA interactions. Journal of Bioinorganic Chemistry. (246), 112303, 2023. https://doi.org/10.1016/j.jinorgbio.2023.112303.
7.- Cassiano Cunha de Souza, José Aleixo de Azevedo-França, Emile Barrias, Stephany C. F.Cavalcante, Eduardo Guimarães Vieira, Ana Maria Da Costa Ferreira, Wanderley de Souza, Maribel Navarro. Silver and copper-benznidazole derivatives as potential antiparasitic metallodrugs: synthesis, characterization, and biological evaluation. Journal of Inorganic Biochemistry, 239, 112047, 2023 https://doi.org/10.1016/j.jinorgbio.2022.112047.
8.- Visbal, Gonzalo; Justo, Rodrigo M. S.; Dos Santos Da Silva e Miranda, Gabrielle; Teixeira de Macedo Silva, Sara; de Souza, Wanderley; Rodrigues, Juliany Cola Fernandes; Navarro, Maribel. Zinc(II)-Sterol Hydrazone Complex as a Potent Anti-Leishmania Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action. Pharmaceutics. v.15, p.1113, 2023.
9.- Wilmer Villarreal, William Castro, Sorenlis González, Marylin Madamet, Rémy Amalvict, Bruno Pradines, Maribel Navarro. Copper (I)-Chloroquine Complexes: Interactions with DNA and Ferriprotoporphyrin, Inhibition of β-Hematin Formation and Relation to Antimalarial Activity. Pharmaceuticals 2022, 15, 921. https://doi.org/10.3390/ph15080921
10.- Caroline de Souza Pereira, Helenita Costa Quadros, Samuel Yaw Aboagye, Diana Fontinha, Sarah D’Alessandro, Margaret Elizabeth Byrne, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Diogo Rodrigo M. Moreira, Nicoletta Basilico, David L. Williams, Miguel Prudêncio, Bruno Pradines and Maribel Navarro. A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis. Pharmaceutics, 14, 1251, 2022. https://doi.org/10.3390/pharmaceutics14061251
11.- Jose Aleixo de Azevedo França, Emile Barrias, Chris Hebert Jesus Franco, WilmerVillarreal, Eduardo GuimarãesVieira, Ana Maria Da Costa Ferreira, Wanderley de Souza, Maribel Navarro*. Promising fluconazole based zinc(II) and copper(II) coordination polymers against Chagas disease. Journal of Bioinorganic Chemistry. 233, 111834, 2022. https://doi.org/10.1016/j.jinorgbio.2022.111834
12.- Camila A. S. R. Conde, Mauro V. Almeida, Gabrielle S. Silva, Milena B. P. de A. Sodre; Juliany C. F. Rodrigues, Maribel Navarro. Synthesis, characterization and antileishmanial activity of copper(II) and zinc(II) complexes with diamine ligands. Transition Metal Chemistry, 47, 147–156, 2022 https://doi.org/10.1007/s11243-022-00495-7
13.- Rodrigo M. S. Justo, Luana Pereira Borba-Santos, Youssef Bacila Sade, Frederico Henrique C. Ferreira, Nathalia M. P. Rosa,d Luiz Antonio S. Costa, Gonzalo Visbal, Sonia Rozental, Maribel Navarro. Synthesis, characterization and biological evaluation of zinc and copper azasterol complexes against Sporothrix brasiliensis New Journal of Chemistry. 45, 20840—20849, 2021.
14.- Jose Aleixo de Azevedo França, Luana Pereira Borba-Santos, Giovana de Almeida Pimentel, Chris Hebert Jesus Franco, Cassiano Souza, Jaqueline de Almeida Celestino, Emanuella Figueiredo de Menezes, Nathalia Pinheiro dos Santos, Eduardo Guimarães Vieira, Ana Maria Da Costa Ferreira, Wanderley de Souza, Sonia Rozental, Maribel Navarro. Antifungal promising agents of Zinc(II) and Copper(II) derivatives based on azole drug. Journal of Bioinorganic Chemistry. 219, 111401, 2021.
15.- Juliane Aparecida Marinho, Daniel Silqueira Martins Guimarães, Nícolas Glanzmann, Giovana de Almeida Pimentel, Izabelle Karine da Costa Nunes, Henrique Marcelo Gualberto Pereira, Maribel Navarro, Fernando de Pilla Varotti, Adilson David da Silva, Clarice Abramo. In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization. European Journal of Medicinal Chemistry, 215, 113271, 2021. https://doi.org/10.1016/j.ejmech.2021.113271
16.-Caroline de Souza Pereira, Helenita Costa Quadros, Diogo Rodrigo Magalhaes Moreira, William Castro, Romulo Ivisson Santos De Deus Da Silva, Milena Botelho Pereira Soares, Diana Fontinha, Miguel Prudêncio, Vinicius Schmitz, Hélio F. Dos Santos, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Bruno Pradines, and Maribel Navarro. A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent. Chemical Medicinal Chemistry. Volume 16, Issue 4, 662-678, 2021.
17.-Maribel Navarro, Rodrigo M. S. Justo, Giset Y. Sánchez Delgado, Gonzalo Visbal. Metallodrugs for the treatment of Trypanosomatid diseases: recent advances and new insight. Current Pharmaceutical Design. 27(15):1763-1789, 2021. DOI : 10.2174/1381612826666201113104633
18.- Giset Y. Sánchez Delgado*, Camila A. S. R. Condéa, Hélio F. Dos Santos, Maribel Navarro. Quimica Nova. Vol. 43, No. 8, 1104-1124, 2020.
19.- Azevedo-Franca J. A.; Granado R. ; Silva S. T. M.; Santos-Silva G.; Scapin S.; Borba-Santos L. P.; Rozental S.; de Souza Wanderley; Martins-Duarte Erica S.; Barrias E.; Rodrigues J. C. F.*; Navarro, Maribel*. Synthesis and Biological Activity of Novel Zinc-Itraconazole Complexes in Protozoan Parasites and Sporothrix spp. Antimicrobial Agents and Chemotherapy v. 64, p. 1, 2020.
20.- Pereira Livia Dessupoio; Vila, Taissa ; Borba-Santos, Luana Pereira ; de Souza, Wanderley; Navarro Maribel ; Rozental Sonia. Activity of Metal-Azole Complexes against Biofilms of Candida albicans and Candida glabrata. Current Pharmaceutical Design, v. 26, p. E1-E8, 2020.
21.- Victor Midlej, Felipe Rubim, Wilmer Villarreal, Érica S. Martins-Duarte, Maribel Navarro, Wanderley de Souza, Marlene Benchimol. Zinc-clotrimazole complexes are effective against Trichomonas vaginalis. Parasitology. v. 146, p. 1-11, 2019.
22.- Legna Colina-Vegas, Joseane Lima Prado Godinho, Thallita Coutinho, Rodrigo S. Correa,Wanderley de Souza, Juliany Cola Fernandes Rodrigues, Alzir Azevedo Batista, Maribel Navarro. Antiparasitic activity and ultrastructural alterations provoked by organoruthenium complexes against Leishmania amazonensis. New Journal of Chemistry. 2019, 43, 1431—1439.
Patent application
Gonzalo Visbal, Maribel Navarro, Rodrigo Justo, Juliany Rodrigues, Sara Macedo-Silva, Wanderley de Souza, G. S Silva. Composto Metaloazasterol Inibidor da Enzima Delta 24-Esterol Metiltransferase, Composição Farmacêutica e Uso do Composto. 2020, Brasil. Patente: Privilégio de Inovação. Número do registro: BR1020200191217. Granted 06/14/2022.